11220E500100 College of Engineering Seminar
工學院英文書報討論

主題 TOPIC
▸　Point-of-Use (PoU) Diagnostics using Magnetic and Bioelectronic Approaches

摘要 Abstract
❝　Facing unprecedented population-ageing, the growing impact of noncommunicable diseases (NCDs) necessitates evolution in the contemporary healthcare system that was designed many decades ago. One of the key enablers is to transition diagnostics from centralized laboratories closer to patients in point-of-use (PoU) settings, which provide high effectiveness, low cost, easy access, and fast turnaround. Optical-based instrumentation is still the workhorse in clinical diagnostics, while it hardly translates to a PoU device due to requirement of complex optics, lasers, and photodetectors. 
❝　To better address NCD management, a magnetic biosensor provides PoU-friendly settings like matrix-insensitivity, rapid turnaround time, and miniaturization without a loss of sensitivity. In this talk, magneto-biosensing techniques are presented with both cellular and molecular assays. A magnetic flow cytometer (MFC) using a giant magnetoresistive (GMR) biosensor and matched filtering is developed to perform aptamer-based cancer cell detection, exhibiting an affordable signal-to-noise ratio (SNR) down to 2.5 dB. In terms of the molecular assay, magnetorelaxometry (MRX) is implemented with GMR sensors and bioelectronics, demonstrating the first realization of GMR-based time-domain MRX bioassays.　❞

講者 SPEAKER
▸　黃至正教授 Prof. Chih-Cheng HUANG
▸　國立清華大學生命科學暨醫學院精準醫療博士學位學程 Precision Medicine Ph.D. Program, College of Life Sciences and Medicine, National Tsing Hua University

時間 TIME
▸　2024/04/30 (TUE) 13:20 ~ 15:10

地點 VENUE
▸　化工館202教室 Classroom 202, Chemical Engineering Building