11410E500100 工學院英文書報討論／Seminar

主題 TOPIC
▸　Nanocarrier-Driven Immune Remodeling Ignites Cold Tumors

❝　The clinical efficacy of cancer immunotherapy remains limited in many solid tumors due to the presence of immunosuppressive microenvironments, dense extracellular matrix (ECM) barriers, and aberrant vasculature, all of which impede drug penetration and immune cell infiltration. This talk highlights our recent advances in engineering nanocarriers to reprogram the tumor microenvironment and enhance anti-tumor immune responses. We demonstrate how the targeted delivery of small molecules, therapeutic gases, genes, cytokines, and enzymes via nanoscale platforms can normalize tumor vasculature, increase T cell infiltration, and synergize with cancer vaccines and immune checkpoint blockade across various malignancies. Furthermore, we present an in situ gel-based cancer vaccine incorporating chemo-immunotherapeutic agents, STING agonists, or engineered dendritic cells to promote immunogenic cell death and durable post-surgical anti-tumor immunity. By utilizing rational nanocarrier design, we achieve precise modulation of both stromal and immune compartments—showing the potential of nanotechnology to convert “cold” tumors into immunologically active ones and offering a blueprint for clinically translatable strategies in combination immunotherapy. 　❞

講者 SPEAKER
▸　陳韻晶教授 Prof. Yun-Ching Chen
▸　國立清華大學生物醫學工程研究所 Institute of Biomedical Engineering, National Tsing Hua University
▸　更多資訊：CV

時間 TIME
▸　2025/09/16 (TUE) 13:20 ~ 15:10

地點 VENUE
▸　工程一館215教室 Classroom 215, Engineering Building 1